Among them, atypical protein kinase C (aPKC) is likely the most studied kinase in cell polarity and has the largest number of downstream substrates characterized so far. More than half of the polarity proteins that are essential for regulating cell polarity have been identified as …

Jun 25, 2018 · More than half of the polarity proteins that are essential for regulating cell polarity have been identified as aPKC substrates. This review covers mainly studies of aPKC in regulating anterior-posterior polarity in the worm one-cell embryo and apical-basal polarity in epithelial cells and asymmetrically dividing cells (for example, Drosophila ...

Atypical Protein Kinase Cs (aPKCs) are a group of protein kinases with an evolutionarily conserved role in regulating cell polarity—a feature central to essentially all aspects of neuronal biology.

Feb 19, 2025 · Results identify the Cdc42/Par6/atypical protein kinase C (aPKC) Par polarity complex as uniquely and specifically regulating apoptosis-induced compensatory proliferation in Drosophila epithelia. Data show that Zif is a transcription factor that directly represses aPKC transcription [Zif].

Dec 17, 2018 · Our study reveals that aPKC controls physiological and pathological vascular growth by regulating the transcriptional activity and abundance of key transcription factors FoxO1 and c-Myc....

Sep 15, 2022 · Here, we uncover how Drosophila aPKC maintains epithelial architecture by directly observing tissue disorganization after fast optogenetic inactivation in living adult flies and ovaries cultured ex vivo.

Atypical protein kinase C (aPKC) isoforms are overexpressed and activated in many cancer types. Using normal, highly polarized epithelial cells (MDCK and NMuMG), we report that aPKC gain of function overcomes contact inhibited growth and is sufficient for a …

examine some of the diverse physiological outcomes of aPKC's function in differentiation, along with the molecular pathways that control aPKC and those that are responsive to changes in its catalytic activity.

Aug 8, 2009 · Atypical protein kinase C (aPKC) is a serine/threonine kinase that is recruited to the cell membrane via its interaction with the scaffolding PDZ-domain proteins Par3 and Par6 and is activated by the Rho-GTPase Cdc42 (Joberty et al., 2000; Lin et al., 2000).

Jun 25, 2018 · Among them, atypical protein kinase C (aPKC) is likely the most studied kinase in cell polarity and has the largest number of downstream substrates characterized so far. More than half of...