Induced pluripotent stem cells reveal differences between humans …
Oct 23, 2013 · The team plans to differentiate the stem cells into other tissues, such as neurons, and compare how the cells from different species behave. They will also use the iPSC …
Human-specific genetics: new tools to explore the molecular and ...
Feb 3, 2023 · In this Review, we describe how the sequencing of genomes from modern and archaic hominins, great apes and other primates is revealing human-specific genetic changes …
Generation and characterization of induced pluripotent stem cells …
Mar 19, 2025 · These signatures highlighted processes linked to genomic stability and cell death, providing insights into small ape-specific adaptations. This study positions small ape iPSCs as …
Molecular signature of primate astrocytes reveals pathways and ...
Feb 4, 2025 · We show that genes and pathways implicated in long-range intercellular signaling are activated in the human iAstrocytes and partake in controlling iAstrocyte complexity. Genes …
HAND1, partially mediated through ape-specific LTR binding, is ...
Liu et al. show that activin A promotes BMP4-treated human iPSC differentiation into ExMC and uncover the essential role of HAND1 in this process. In turn, ExMC secretes extracellular …
The impact of induced pluripotent stem cells in animal conservation
Jan 16, 2024 · IPSC technology offers novel approaches and techniques for obtaining pluripotent stem cells (PSCs) from rare and endangered animal species. Successful generation of iPSCs …
Reverse Engineering Human Brain Evolution Using Organoid Models
Using ape iPSC lines to characterize tolerated variation in gene regulation and developmental processes within primates species may further support interpretation of candidate human …
Induced Pluripotent Stem Cells: Problems and Advantages …
Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be obtained by reprogramming animal and human differentiated cells. In this review, issues related to the …
Comparison of induced neurons reveals slower structural and
Jan 20, 2021 · Induced pluripotent stem cells (iPSCs) that can be generated from somatic cells have expanded the possibilities to compare neurogenesis among apes (Otani et al., 2016; …
Harnessing pluripotent stem cells as models to decipher human …
Apr 20, 2021 · Here, we review the potential and growing application of induced pluripotent stem cells (iPSCs) as an emerging model system with which to tackle questions of human evolution …