Anoikis is a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellular matrix (ECM). [1] Usually cells stay close to the tissue to which they belong since the communication between proximal cells as well as between cells and ECM provide essential signals for growth or survival.

Anoikis is a programmed cell death occurring upon cell detachment from the correct extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing dysplastic cell growth or attachment to an inappropriate matrix.

Dec 1, 2013 · Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix, behaving as a critical mechanism in preventing adherent-independent cell growth and attachment to an inappropriate matrix, thus avoiding colonizing of distant organs.

Oct 25, 2005 · Apoptosis in response to inappropriate cell/ECM interactions is termed anoikis, a name that in some way implies a special case of cell death initiated by signals not used in...

Mar 14, 2023 · Most cells require attachment to the extracellular matrix (ECM) for survival, and upon detachment undergo a form of apoptotic cell death called anoikis. However, some cells, prominently cancer...

Anoikis is the name given to the induction of apoptosis in cells upon loss of attachment to the extracellular matrix (ECM) and neighboring cells. The relationship between cell adhesion and apoptosis was first elucidated and defined by Steven M. Frisch and Hunter Francis in 1994.

Jul 13, 2022 · One of the hallmarks of aggressive cancer cells is the ability to evade detachment-induced programmed cell death called anoikis, allowing them to survive in unfavorable extracellular matrix (ECM)-deprived metastatic conditions.

Anoikis is a programmed cell death occurring upon cell detachment from the correct extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing dysplastic cell growth or attachment to an inappropriate matrix.

Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant.

Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes.