Ampakines or AMPAkines are a subgroup of AMPA receptor positive allosteric modulators with a benzamide or closely related chemical structure. [1][2] They are also known as "CX compounds". [1] .

Ampakines are a structurally diverse family of small molecules that positively modulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors, and thereby enhance fast, excitatory transmission throughout the brain. Surprisingly, ampakines have discrete effects on brain activity and behavior.

Mar 25, 2024 · Ampakines are a class of nootropic compounds that positively modulate AMPA receptors in the brain. AMPA receptors are critical for glutamate transmission and synaptic plasticity, which are fundamental processes in learning, memory, and overall cognitive function.

Ampakines are the first peripherally administered drugs that increase excitatory monosynaptic responses in the brain. Because of this effect, the compounds improve communication in complex networks, potently facilitate long-term potentiation (LTP) and induce the expression of neurotrophic factors.

Jan 26, 2024 · Let's tackle the tricky topic of how much ampakine is just right for you. I'll guide you through personalizing your dosage and creating a regimen that fits your unique needs. Plus, I'll clue you in on how your diet can play a supportive role in maximizing the benefits of ampakines.

Recent demonstrations that positive modulators of AMPA-type glutamate receptors (ampakines) increase neuronal brain-derived neurotrophic factor (BDNF) expression have suggested a novel strategy for treating neurodegenerative diseases.

Feb 1, 2006 · Ampakines are a structurally diverse family of small molecules that positively modulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors, and thereby enhance fast, excitatory transmission throughout the brain. Surprisingly, ampakines have discrete effects on brain activity and behavior.

Ampakines are a class of drugs that modulate neurotransmitters in the brain. One of the major neurotransmitters is glutamate, and a reduced level of glutamate-mediated excitatory stimulation has been implicated in Alzheimer’s disease, schizophrenia, and a number of …

Ampakines are drugs structurally derived from aniracetam that potentiate currents mediated by AMPA type glutamate receptors. These drugs slow deactivation and attenuate desensitization of AMPA receptor currents, increase synaptic responses and enhance long-term potentiation.

Ampakines have a broad range of potential therapeutic applications. These include relief of the effects of sleep deprivation, poor memories, stupidity (yes, they could be smart drugs!), Alzheimers, other forms of dementia, autism, schizophrenia, and general cognitive decline.