The ALX3 gene, also known as aristaless-like homeobox 3, is a protein coding gene that provides instructions to build a protein which is a member of the homeobox protein family. [5][6][7] This grouping regulates patterns of anatomical development.

Mar 28, 2025 · ALX3 (ALX Homeobox 3) is a Protein Coding gene. Diseases associated with ALX3 include Frontonasal Dysplasia 1 and Crouzon Syndrome . Among its related pathways are MITF-M-dependent gene expression and Nervous system development .

The ALX3 gene provides instructions for making a protein that is a member of the homeobox protein family. Homeobox proteins direct the formation of body structures during early embryonic development.

Title: Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma. Chromatin immunoprecipitation assays indicated that Alx3 in mouse pancreatic islets occupies the promoter of the mouse insulin genes.

Using phylogenetics and comparative genomics, we show that the common ancestor of jawed vertebrates had three Alx genes descendent from the two-round genome duplications (Alx1, Alx3, Alx4), compared with a single amphioxus gene.

Mar 2, 2025 · The ALX3 gene (ALX3 stands for: ALX Homeobox 3) is a protein-coding gene located on chromosome 1p13.3. Associated signaling pathways include MITF-M-dependent gene expression and nervous system development. An important paralog of this gene is ALX4.

The ALX3 (ALX homeobox 3) is a protein-coding gene located on chromosome 1. The ALX3 gene gives instructions for making a protein that's part of the homeobox protein family. These proteins guide the formation of body parts during early embryonic development.

Alx3 is a paired class aristaless-like homeoprotein expressed during embryonic development. Transcriptional transactivation by aristaless-like proteins has been associated with cooperative dimerization upon binding to artificially generated DNA consensus sequences known as P3 sites, but natural target sites in genes regulated by Alx3 are unknown.

Feb 8, 2025 · This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated …

This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator inv olved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors.