Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is, beta cells) when administered to rodents and many other animal species. …

Jan 1, 2017 · Alloxan is one of the common diabetogenic agents often used to assess the antidiabetic potential of both pure compounds and plant extracts in studies involving diabetes.

Alloxan is synthesized by uric acid oxidation and exerts its diabetogenic action by intravenous, intraperitoneal, or subcutaneous administration. Alloxan evokes insulin release for a short …

Alloxan is a member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups. It has a role as a …

Feb 1, 2016 · Alloxan is a thermally stable white solid with an unusual structure. Its formal name is 2,4,5,6(1 H ,3 H )-pyrimidinetetrone, indicating that it has a pyrimidine ring structure with four …

We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. However, we experienced an inconsistent and unpredictable response with …

Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter. In the presence of intracellular thiols, …

Dec 18, 2024 · Alloxan (CAS 50-71-5) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS …

The meaning of ALLOXAN is a crystalline compound C4H2N2O4 causing diabetes mellitus when injected into experimental animals.

Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas when administered to rodents and many other animal species, and has been shown …