Mar 1, 2025 · Find discussions and information on various topics in the jbcam forum.

Aug 1, 2020 · Comparative studies have demonstrated that extensive cell to cell contacts, cell to matrix interactions and wild type ALCAMs are crucial components for converting pro-MMP2 to the active form presented in metastatic melanoma cite.

Feb 8, 2025 · Activated leukocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis. this study establishes for the first time that CD166 is the ligand of ILT3.

Jan 24, 2017 · Activated leukocyte cell adhesion molecule (ALCAM) is a cell adhesion molecule found on blood-brain barrier endothelial cells (BBB-ECs) that was previously shown to be involved in leukocyte transmigration across the endothelium.

Activated leukocyte cell adhesion molecule (ALCAM) is a cell adhesion molecule found on blood–brain barrier endothelial cells (BBB-ECs) that was previously shown to be involved in leukocyte transmigration across the endothelium.

Feb 16, 2018 · We previously identified Activated Leukocyte Cell Adhesion Molecule (ALCAM) as a clinically relevant driver of metastasis and hypothesized that a tunable mechanism of ectodomain shedding...

ALCAM is a cell surface glycoprotein structurally related to the immunoglobulin superfamily, with 10 potential N-glycosylation sites in its extracellular domain (ED), a transmembrane and a short cytoplasmic domain.

ALCAM functions as a cell–cell adhesion molecule and engages in homotypic (ALCAM–ALCAM) and heterotypic (ALCAM–CD6) interactions between adjacent cells. These interactions are mediated through its most amino-terminal V domain (D1).

Feb 8, 2025 · A Novel Regulatory Role of Activated Leukocyte Cell-Adhesion Molecule in the Pathogenesis of Pulmonary Fibrosis. The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses. Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers.

ALCAM (activated leukocyte cell adhesion molecule) is an important regulator in human cancers, particularly solid tumours. Its expression in cancer tissues has prognostic values depending on cancer types and is also linked to distant metastases.