Aminolevulinic acid synthase (ALA synthase, ALAS, or delta-aminolevulinic acid synthase) is an enzyme (EC 2.3.1.37) that catalyzes the synthesis of δ-aminolevulinic acid (ALA) the first …

Dec 17, 2018 · One of the small signaling molecules utilized is 5-aminolevulinic acid (ALA) that has been shown to enhance plant growth under abiotic stress. As a metabolic intermediate in …

ALAS is the key enzyme for 5-ALA synthesis via the C4 pathway, and its isoenzymes are encoded by different redundant genes (Kang et al., 2012). Tai et al. (1988) identified the two …

In non-photosynthetic eukaryotes such as animals, fungi, and protozoa, as well as the class Alphaproteobacteria of bacteria, it is produced by the enzyme ALA synthase, from glycine and …

There are good reasons for two synchronous control mechanisms of ALA synthesis in plants. In angiosperms, ALA biosynthesis is repressed during darkness, to prevent excessive …

Nov 1, 2022 · With the development of metabolic engineering and synthetic biology, the biosynthesis of 5-ALA has attracted increasing attention. 5-Aminolevulinic acid synthase …

In non-plant eukaryotes, 5-aminolevulinic acid synthase (ALAS) catalyzes the first committed step of heme biosynthesis, the condensation of glycine and succinyl-CoA to yield 5-aminolevulinic …

Feb 26, 2015 · 5-Aminolevulinic acid (ALA), the committed intermediate of the heme biosynthesis pathway, shows significant promise for cancer treatment. Here, we identified that in addition to …

The first step enzyme, 5-aminolevulinic acid (ALA) synthase, is coded for by two genes, one erythroid-specific (ALA synthase-2 on chromosome X) and one ubiquitous (ALA synthase-1 on …

ALA synthase catalyzes the condensation of glycine and succinyl coenzyme A to form ALA using pyridoxal phosphate as a cofactor (Figure 3). The enzymology of mammalian ALA synthase is …