AKT2, also known as RAC-beta serine/threonine-protein kinase, [5] is an enzyme that in humans is encoded by the AKT2 gene. [6] It influences metabolite storage as part of the insulin signal transduction pathway. [5]

Mar 30, 2025 · AKT2 (AKT Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with AKT2 include Hypoinsulinemic Hypoglycemia With Hemihypertrophy and Akt2-Related Familial Partial Lipodystrophy .

Activated AKT2, which is primarily expressed in insulin-responsive tissues, promotes translation of glucose transporter 4 (GLUT4). And the direct target of AKT is a substrate of 160 kDa (AS160), also known as TBC1D1 29 .

Feb 8, 2025 · AKT2 drives cancer progression and is negatively modulated by miR-124 in human lung adenocarcinoma. A novel miRNA located in the GATA4 gene regulates the expression of IGF-1R and AKT1/2 genes and controls cell proliferation. miR-664b-5p Inhibits Hepatocellular Cancer Cell Proliferation Through Targeting Oncogene AKT2.

Feb 8, 2025 · Title: Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer. m 6 A reader IGF2BP1 reduces the sensitivity of nasopharyngeal carcinoma cells to Taxol by upregulation of AKT2.

AKT is a central protein in many cellular pathways such as cell survival, proliferation, glucose uptake, metabolism, angiogenesis, as well as radiation and drug response. The three isoforms of AKT (AKT1, AKT2 and AKT3) are proposed to have different ...

Aug 8, 2017 · AKT2 is a serine/threonine kinase that plays a critical role in transducing insulin stimulation into metabolic responses in target tissues, including liver, adipose tissue, and skeletal muscle.

Akt, also known as Protein kinase B (PKB), is a serine-threonine kinase with important roles in proliferation, metabolism, cell differentiation, survival, etc (1, 2). There are three distinct Akt isoforms encoded by three separate genes, namely Akt1/PKBα, Akt2/PKBβ and Akt3/PKBγ.

Nov 11, 2011 · AKT2 encodes a protein belonging to a subfamily of serine/threonine kinases containing Src homology 2 (SH2)-like domains (Cheng et al., 1992). Staal (1987) cloned AKT1 (164730) and AKT2, 2 putative cellular homologs of the v-akt oncogene of the retrovirus AKT8. Cheng et al. (1992) cloned AKT2 cDNA.

AKT2 is a serine/threonine kinase that is an effector molecule in the insulin signaling pathway linked to insulin’s metabolic effects.