Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. [5] [6]

Mar 28, 2025 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma . Among its related pathways are lorlatinib-resistant ALK mutants and GPCR Pathway .

The ALK gene provides instructions for making a protein called ALK receptor tyrosine kinase, which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this gene and related health conditions.

Jan 22, 2025 · This gene change is called an ALK fusion or ALK rearrangement and can cause cancer. When this fusion happens, a patient is said to be ALK-positive. The most common gene that ALK fuses with is called EML4.

Mar 7, 2025 · Genetic alterations of ALK in cancer include chromosomal rearrangements, activating point mutations or ALK protein overexpression that typically supports oncogenesis by inducing constitutive...

Anaplastic lymphoma kinase (ALK) is correlated with oncogenesis in different types of cancers, such as anaplastic large cell lymphoma, lung cancer, neuroblastoma, and even breast cancer, by abnormal fusion of ALK or non-fusion ALK activation.

In 1997, several studies reported essential findings related to wild-type ALK [3, 4]. The human ALK gene is located at chromosome region 2p23.2–p23.1. This gene, which contains 26 exons, encodes the full-length ALK protein with 1620 amino acids.

Nov 24, 2021 · Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates important functions in the central nervous system 1, 2. The ALK gene is a hotspot for chromosomal...

ALK, anaplastic lymphoma kinase, is a receptor in the insulin receptor superfamily and is a key regulator of neuronal development (PMID: 21502284) and also promotes cell proliferation through activation of MAPK and PI3K signaling pathways (PMID: 27573755).

Feb 1, 2010 · ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily. The function of the full-length ALK receptor is poorly understood. It has a probable role in the central and peripheral nervous system development and maintenance.