Nov 25, 2023 · For most causes of AKI, renal blood flow reduction is a common pathologic pathway for declining GFR. The pathophysiology of AKI has traditionally been divided into three categories: prerenal, intrinsic renal (ie, intrarenal), and postrenal.

Dec 1, 2019 · Prerenal acute kidney injury is associated with decreased renal perfusion and glomerular filtration rate (GFR) caused by intravascular volume depletion secondary to hypovolemia, peripheral...

Acute kidney injury (AKI) is an abrupt and usually reversible decline in the glomerular filtration rate (GFR). This results in an elevation of serum blood urea nitrogen (BUN), creatinine, and other metabolic waste products that are normally excreted by the kidney.

Reduction in the GFR, secondary to kidney injury, is the hallmark of AKI and results in increased levels of blood urea nitrogen (BUN) and serum creatinine. Unfortunately, the rates of increase in BUN and serum creatinine do not parallel the fall in GFR in a time frame that is clinically useful.

In summary, the rapid and accurate measurement of GFR in AKI is important for diagnosis, severity of injury stratification, and potential therapeutic purposes. Rapid identification and determination of the extent of AKI will allow for early treatment, including dialysis initiation, as well as enrollment and stratification in clinical studies.

Feb 11, 2025 · The term AKI has largely replaced acute renal failure (ARF), reflecting the recognition that smaller decrements in kidney function that do not result in overt organ failure are of substantial clinical relevance and are associated with increased morbidity and mortality.

An ideal definition of recovery would compare the gold standard of GFR measurement before and after the episode of AKI. Even better would be the inclusion of an assessment of renal functional reserve before and after the episode of AKI.

Stage 1: Kidney damage (e.g. proteinuria) and normal GFR; GFR >90; Stage 2: Kidney damage (e.g. proteinuria) and mild decrease in GFR; GFR 60-89; Stage 3: Moderate decrease in GFR; GFR >30-59; Stage 4: Severe decrease in GFR; GFR 15-29; Stage 5: Kidney failure (dialysis or kidney transplant needed); GFR <15; Risk Factors. Radiocontrast agents

Dec 3, 2021 · Acute kidney injury (AKI): rapid deterioration in kidney function; common in hospitalised patients, occurring in up to 20% of admissions. Aetiology: sudden decrease in glomerular filtration rate (GFR); classified into pre-renal, intra-renal, and post-renal causes.

Nov 25, 2023 · Acute kidney injury (AKI), formerly known as acute renal failure (ARF), denotes a sudden and often reversible reduction in kidney function, as measured by glomerular filtration rate (GFR).[1][2][3] There is no clear definition of AKI.