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Luteolin as a potential therapeutic candidate for lung cancer: …
Jul 1, 2024 · It was found that luteolin significantly reduced the mRNA expression levels of AIM2, caspase-1, and IL-1β, thereby inhibiting the activation of the AIM2 inflammasome. Lutein …
AIM2 in health and disease: inflammasome and beyond - PMC
Unlike in colorectal cancers, AIM2 has been found to function as an oncogene that promotes growth and proliferation in an inflammasome-dependent manner in lung carcinoma cell lines …
AIM2 upregulation promotes metastatic progression and PD‐L1 …
Sep 29, 2022 · In addition, AIM2 knockdown predominantly mitigated the EMT progression as judged by an increased level of E‐type marker CDH1 and the decreased levels of M‐type …
- DOI: 10.1111/cas.15584
- Published: 2023/01
- Publication: Cancer Sci. 2023 Jan; 114(1): 306-320.
AIM2 promotes the development of non-small cell lung cancer by ...
Jan 31, 2020 · Here, we demonstrate that the DNA sensor protein absent in melanoma 2 (AIM2) is highly expressed in non-small cell lung cancer (NSCLC) cells and that high AIM2 expression …
- Author: Miao Qi, Dan Dai, Jin Liu, Zhongqi Li, Panpan Liang, Yue Wang, Lu Cheng, Yihong Zhan, Zhifeng An, Ya...
- Publish Year: 2020
New insights into nucleic acid sensor AIM2: The potential benefit …
Feb 1, 2024 · In this review, we provide a systematic summary and discussion of the latest advancements in AIM2 sensing various types of nucleic acids. Additionally, we discuss the …
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Cyclin-dependent kinase inhibitor 1A inhibits …
Mar 15, 2024 · CDKN1A confers radioresistance to A549 and H1650 human lung adenocarcinoma cells. CDKN1A influences radiation-induced pyroptosis in A549 cells and xenograft tumors. CDKN1A inhibits AIM2 inflammasome activation …
Luteolin inhibited the activation of AIM2 …
We found that the expression of AIM2 was highly expressed in H226, A549, A549/Taxol, and H460 cells compared with 16HBE cells (Fig. S2A). In addition, luteolin concentration dependently...
Macrophage IL-1β contributes to tumorigenesis …
Jun 27, 2023 · We show that tumor conditioned media (CM) can induce IL-1β production, indicative of inflammasome activation in primed macrophages. This could be partially dependent on caspase 1/11, AIM2 and NLRP3.
Decrease of AIM2 mediated by luteolin contributes to non-small …
The abilities of luteolin to reduce Vimentin and MMP9 expressions and to enhance E-cadherin expression were impaired in AIM2-knockdown A549 and H460 cells. Furthermore, AIM2 …
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