Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. [5][6][7] ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor.

Mar 30, 2025 · ACVR2A (Activin A Receptor Type 2A) is a Protein Coding gene. Diseases associated with ACVR2A include 2Q23.1 Microduplication Syndrome and Fibrodysplasia Ossificans Progressiva. Among its related pathways are Signaling by TGFB family members and Signaling by NODAL.

There are two activin type two receptors: ACVR2A and ACVR2B. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a type 2 receptor, which recruits and trans-phosphorylates a type I receptor.

Feb 8, 2025 · Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.

Jan 4, 2025 · Title: Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.

Aug 18, 2017 · Here, we generated mice with conditional deletion of activin receptor (ACVR) type 2A, ACVR2B, or both, in osteoblasts, to determine the contribution of activin receptor signaling in regulating bone mass. Immunohistochemistry localized ACVR2A and ACVR2B to …

Apr 1, 2024 · ACVR2A and ACVR2B are constitutively active type II receptors which also contain an extracellular ligand binding domain, and a larger serine/threonine kinase domain (Fig. 1 C). Each type I/type II receptor combination can bind more than one activin dimer to form an active signaling complex.

ACVR2A is a type II receptor that binds to TGF-β ligands and initiates downstream signaling through the Smad proteins. Studies have demonstrated that ACVR2A is essential for embryonic development, cardiovascular function, and tissue homeostasis.

Feb 8, 2025 · Go to Variation Viewer for ACVR2A variants Summary This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes.

Sep 8, 2018 · Aims: Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis.