The acute toxic class method is based on biometric evaluations (2)(3)(4)(5) with fixed doses, adequately separated to enable a substance to be ranked for classification purposes and …

In this study, a comprehensive dataset of 7,385 compounds with their most conservative lethal dose (LD 50) values has been compiled. A combinatorial QSAR approach has been employed …

Aug 30, 2019 · In the framework of a new international collaborative project, the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods and the U.S. Environmental …

Apr 15, 2022 · Herein, we present the largest assembly to date of manually curated rat acute oral toxicity LD 50 data comprising chemicals with more than one experimentally derived LD 50 …

The objective of this study was to assess the acute oral median lethal dose following a single oral administration to female Wistar rats followed by a 14-day observation period. The study was …

Jun 28, 2022 · Based on the observed variability, we were able to quantify a margin of uncertainty of ±0.24 log10 (mg/kg) associated with discrete in vivo rat acute oral LD50 values. Keywords: …

Enhance your chemical risk assessments with our 2025 acute toxicity suite, featuring thousands of new records, dual GHS & CLP categorization, and advanced predictive models for acute rat …

Mar 14, 2011 · The method for QSAR modelling of rat acute toxicity based on the combination of QNA (Quantitative Neighbourhoods of Atoms) descriptors, PASS (Prediction of Activity …

Dec 1, 2010 · Currently, acute oral toxicity is assessed in rats in accordance with the OECD Test Guidelines 420 (OECD, 2001a), 423 (OECD, 2001b), 425 (OECD, 2001c).

In this study, a comprehensive data set of 7385 compounds with their most conservative lethal dose (LD 50) values has been compiled. A combinatorial QSAR approach has been employed …