Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene. [5][6][7] Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA. [6] The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1.

Mar 30, 2025 · ACSL6 (Acyl-CoA Synthetase Long Chain Family Member 6) is a Protein Coding gene. Diseases associated with ACSL6 include Myelodysplastic Syndrome and Leukemia. Among its related pathways are Fatty acid metabolism and arachidonate biosynthesis III (metazoa).

Sep 18, 2024 · Here, we report that long-chain acyl-CoA synthase 6 (ACSL6) is highly expressed in liver cancer and correlated with poor prognosis. ACSL6 promotes tumor growth, metastasis, and immune evasion mediated by IL-18, independent of its metabolic enzyme activity.

Oct 15, 2021 · ACSL6 downregulation has been observed in many forms of cancers, except in colorectal cancer (CRC). Here, we address the differential regulatory mechanisms of the ACSL family members as well as their functions in carcinogenesis.

Apr 7, 2025 · Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice. Shishikura K, et al. FASEB J, 2019 Dec. PMID 31648559, Free PMC Article. Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.

Oct 15, 2021 · ACSL6 downregulation has been observed in many forms of cancers, except in colorectal cancer (CRC). Here, we address the differential regulatory mechanisms of the ACSL family members as well as their functions in carcinogenesis.

Aug 21, 2024 · Acyl-CoA synthetase 6 (Acsl6)-facilitated enrichment of docosahexaenoic acid (DHA) in the retina is essential for rod photoreceptor function, viability and control of basal activity of the...

Aug 29, 2024 · Blocking of ACSL6 impairs the tumor growth and upregulates FLI1, which reduces the levels of COLs and compromises irradiation-induced autophagy, leading to considerable therapeutic benefits during radiotherapy.

Nov 23, 2023 · Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure. Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.

Feb 8, 2025 · Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro. Enables arachidonate-CoA ligase activity and protein homodimerization activity.