Aug 1, 2018 · Two major MMP-responsive strategies have been developed for this purpose: (i) controlling cell penetration via MMP-sensitive PEG deshielding; and (ii) controlling cell penetration by the MMP activatable cell-penetrating peptide (ACPP).

Nov 27, 2024 · Leveraging and therapeutically redirecting tumor MMPs through activatable cell-penetrating peptide (ACPP) technology offers new approaches for tumor-selective drug delivery and for studying how drug payloads engage the tumor immune microenvironment.

This study demonstrates that the tumor targeting of radiolabeled MMP-2/9 ACPPs is most likely caused by the activation in the vascular compartment rather than tumor-specific activation, as suggested earlier.

Jul 5, 2022 · To rigorously demonstrate this, we attach radiosensitizing MMAE warheads to two different classes of tumor-targeted drug carriers (i.e., antibody and activatable cell penetrating peptides (ACPPs))...

Feb 1, 2011 · Activatable cell-penetrating peptides (ACPPs) are a new class of promising molecular imaging probes for the visualization of enzymes in vivo. The cell-penetrating function of a polycationic peptide is efficiently blocked by intramolecular electrostatic interactions with a polyanionic peptide.

To improve specificity and sensitivity for MMP-2, an integrin α (v)β (3)-binding domain, cyclic-RGD, was covalently linked to the ACPP. This co-targeting strategy relies on the interaction of MMP-2 with integrin α (v)β (3), which are known to associate via the hemopexin domain of …

Activatable cell penetrating peptides (ACPPs) are novel in vivo targeting agents comprised of a polycationic cell penetrating peptide (CPP) connected via a cleavable linker to a neutralizing polyanion (Fig. 1A). Adsorption and uptake into cells are …

Jul 7, 2014 · We have designed and tested a new way to selectively deliver HPMA polymer-coated adenovirus type 5 (Ad5) particles into matrix metalloproteinase (MMP)-overexpressing tumor cells. An activatable cell penetrating peptide (ACPP) was designed and attached to the reactive 4-nitrophenoxy groups of HPMA po …

Jul 7, 2014 · ACPPs are activatable cell penetrating peptides (CPPs) with a linker between polycationic and polyanionic domains, and MMP-mediated cleavage releases the CPP portion and its attached cargo to enable cell entry.

Jan 5, 2021 · Activatable cell-penetrating peptide (ACPP) would reduce the cytotoxicity of cell-penetrating peptide (CPP)-based drug delivery system by shielding the negative charge and improve the targeting of CPP when hydrolyzed by characteristic proteases.