The virus replicates and simultaneously hampers other organs expressing ACE2, such as the heart, kidneys, blood vessels, and gastrointestinal tract [26, 37]. The massive epithelial and endothelial cell death and vascular leakage trigger the …

ACE2 is a key regulator of the renin–angiotensin–aldosterone system (RAAS). SARS-CoV-2 causes ACE/ACE2 balance disruption and RAAS activation, which leads ultimately to COVID-19 progression, especially in patients with comorbidities, such as hypertension, diabetes mellitus, and cardiovascular disease.

Jan 11, 2021 · Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the cell...

16 hours ago · ACE2 has been well characterized to be the main cell surface entry receptor for SARS-CoV-2, and TMPRSS2 is known as an important priming enzyme facilitating the virus’s fusion on the cell ...

Severe acute respiratory syndrome (SARS)-Coronavirus 2 (SARS-CoV-2) has recently been identified as the causative agent of a new severe respiratory disorder, known as coronavirus 19 disease (COVID-19), which was first detected in Wuhan, China, in …

Nov 27, 2003 · Here we identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2) 3, 4, isolated from SARS coronavirus (SARS-CoV)-permissive Vero E6 cells, that efficiently binds the S1 domain of the...

Mar 14, 2025 · Both SARS-CoV and SARS-CoV-2 have been identified to use their spike (S) proteins on the virus surface to bind human angiotensin-converting enzyme 2 (hACE2) as the receptor to enter human cells (5, 10). ... All ACE2 constructs were cloned into the pCDNA3.1 vector with their native signal peptides to allow secretory expression. Because of the ...

Dec 30, 2020 · ACE2 is the doorway through which SARS-CoV-2 gains entrance into human cells, with the spike proteins of the virus being the keys that unlock the doorway. The spike proteins have high affinity to ACE2. These spikes bind to the ACE2 membrane, freeing the virus to enter the human cell.

Feb 7, 2025 · Two coronaviruses related to MERS-CoV, which infect European Pipistrellus bats, have been found to use ACE2 as their receptor. These viruses target an ACE2 surface region distant from those recognized by other known ACE2-using coronaviruses, highlighting convergent evolution in their adaptation to utilize ACE2.

May 14, 2020 · The ACE2 receptor allows the virus that causes COVID-19 to infect and destroy our cells. What is the normal role of ACE2 in the body, and could it be the key to blocking infection?