In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.

The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L. This area under the curve is dependant on the rate of elimination of the …

In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.

Nov 1, 2024 · AUC in pharmacokinetics (Area Under the Curve) is a vital parameter of the plasma level time curve. AUC is also known as the zero moment curve. It is a crucial measure of the bioavailability of a drug after administration. Also, the Area under the curve is a vital factor used in bioequivalence studies.

In pharmacology, relative bioavailability measures the bioavailability (estimated as the AUC) of a formulation (A) of a certain drug when compared with another formulation (B) of the same drug, usually an established standard, or through administration via a different route.

Apr 2, 2025 · In non-compartmental analysis (NCA), the area under the concentration-time curve (AUC) is a key parameter used to quantify total drug exposure over time. Along with Cmax, AUC is a fundamental parameter for assessing systemic drug exposure and is commonly used for comparisons in pharmacokinetic studies.

A measure of how much drug reaches a person's bloodstream in a given period of time after a dose is given. The information is useful for determining dosing and for identifying potential drug interactions.

The area under the concentration vs. time curve is a useful description of exposure of drug following administration. There are different ways in which AUC may be calculated, and terminology may vary from one source or text to another.

The AUC is of particular use in estimating bioavailability of drugs, and in estimating total clearance of drugs (ClT). Following single intravenous doses, AUC = D/ClT, for single compartment systems obeying first-order elimination kinetics; alternatively, AUC = C0/kel.

Sep 13, 2021 · In general, antibiotics can be categorized as time-dependent, concentration-dependent, or area-under-the-curve (AUC)-dependent killers. In addition to differentiating between these categories, we...