Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene. [5] The protein encoded by this gene belongs to the family of Na + /K + and H + /K + ATPases beta chain proteins, and to the subfamily of Na + /K + -ATPases.

Mar 30, 2025 · ATP1B1 (ATPase Na+/K+ Transporting Subunit Beta 1) is a Protein Coding gene. Diseases associated with ATP1B1 include Hypertension, Essential and 3-Methylcrotonyl-Coa Carboxylase Deficiency. Among its related pathways are …

Jan 4, 2025 · ATP1B1 is epigenetically silenced by promoter methylation in both renal cell carcinoma (RCC) patients' tissues and cell lines. A polymorphic 3'UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure.

Jun 1, 2021 · In this study, we report increased expression of human ATPase Na + /K + transporting subunit β 1(ATP1B1) after DNA and RNA virus infections. We found that the expression of ATP1B1 can inhibit viral replication and increase the levels of IFNs, IFN-stimulated genes, and inflammatory cytokines.

Jan 4, 2025 · Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle.

Jan 4, 2025 · Clinical resource with information about ATP1B1, A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels., Common variants at ten loci modulate the QT interval duration in the QTSCD Study., Essential hypertension, genetic, Genetic association study ...

Our first main finding is that ATP1B1 is more strongly expressed in CN-AML than normal BM (Figure 1A and 1B), which suggests ATP1B1 plays an active role during the pathogenesis of leukemia. The higher ATP1B1 expression was easily detected using qPCR, which is readily applicable for clinical use.

Jun 1, 2021 · In this study, we report increased expression of human ATPase Na + /K + transporting subunit β 1 (ATP1B1) after DNA and RNA virus infections. We found that the expression of ATP1B1 can inhibit viral replication and increase the levels of IFNs, IFN-stimulated genes, and inflammatory cytokines.

Expressed in a circadian manner in the kidney and aorta (at protein level) (PubMed: 30012868). The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A (By similarity).

Jun 17, 2019 · All IOPNs evaluated were found to have recurring fusions of ATP1B1–PRKACB (n = 13), DNAJB1 – PRKACA (n = 6), or ATP1B1 – PRKACA (n = 4). These fusions also were found in corresponding invasive PDACs and intrahepatic CCAs, as well as in matched pancreatic cyst fluid and bile duct brushings.