ARID1A prevents squamous cell carcinoma initiation and
Dec 12, 2019 · Mechanistic studies revealed that ARID1A blocked the interaction between cyclin-dependent kinases (CDKs) and retinoblastoma protein (Rb), reducing the phosphorylation of …
ARID1a as a marker of prognosis and increased sensitivity to …
May 26, 2019 · Loss of function ARID1a mutations may sensitize cancer cells to CDK4/6, mTOR1/2, and SHP1/2 inhibitors in vitro. Further research in ARID1a mutated ER+ BCs using …
Cyclin-dependent kinase pathway aberrations in diverse …
Feb 19, 2025 · There was also a statistically significant association between aberrant ARID1A, an epigenetic regulator that is known to be a tumor suppressor, 23 and abnormal CDK elements. …
ARID1A loss promotes RNA editing of CDK13 in an ADAR1 …
Jun 5, 2024 · Our findings indicate that the deficiency of ARID1A leads to an increase in RNA editing levels and alterations in RNA editing categories mediated by adenosine deaminases …
ARID1A prevents squamous cell carcinoma initiation and
Mechanistic studies revealed that ARID1A blocked the interaction between cyclin-dependent kinases (CDKs) and retinoblastoma protein (Rb), reducing the phosphorylation of Rb. …
ARID1 proteins: from transcriptional and post-translational …
Although a tumor-suppressive role of ARID1A was well established in colorectal cancer, the presence of ARID1A is crucial for proliferation of KRAS-mutated colorectal cancer cells due to …
The Role of the AT-Rich Interaction Domain 1A Gene (ARID1A) in …
Dec 19, 2023 · This review will examine the molecular mechanisms of ARID1A as a tumour suppressor, the role of ARID1A in human cancers, and some of the synthetically lethal …
ARID1A deficiency promotes mutability and potentiates …
May 7, 2018 · In a proteomic screen, we found that ARID1A interacts with mismatch repair (MMR) protein MSH2. ARID1A recruited MSH2 to chromatin during DNA replication and promoted …
Arid1a regulates cell cycle exit of transit-amplifying cells by ...
Using the continuously growing adult mouse incisor model, we show that Arid1a maintains tissue homeostasis through limiting proliferation, promoting cell cycle exit and differentiation of TACs …
ARID1A suppresses R-loop-mediated STING-type I interferon …
May 15, 2024 · ARID1A loss in tumor cells triggers anti-tumor immunity via R-loop-derived cytosolic DNA and activation of the STING-type I interferon pathway, defining a molecular …
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