The TSC1 – TSC2 complex: a molecular switchboard controlling cell growth
A primary mechanism by which mTORC1 senses the status of intracellular ATP is through direct phosphorylation of TSC2 by AMPK (AMP-dependent protein kinase) [98,99].
TSC2 Mediates Cellular Energy Response to Control Cell …
Nov 26, 2003 · Under energy starvation conditions, the AMP-activated protein kinase (AMPK) phosphorylates TSC2 and enhances its activity. Phosphorylation of TSC2 by AMPK is required …
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Apr 25, 2008 · AMPK phosphorylation of the TSC2 tumor suppressor contributes to suppression of mTORC1; however, TSC2-deficient cells remain responsive to energy stress. Using a …
The regulation of AMPK beta1, TSC2, and PTEN expression by …
Apr 1, 2007 · This study explores four p53-regulated gene products, the beta1 and beta2 subunits of the AMPK, which are shown for the first time to be regulated by the p53 protein, TSC2, …
AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2 ...
The effectiveness of PTX-activated AMPK against mTORC1 was determined in cell systems that allowed the separation of the roles of TSC2, p53, and Sestrin2. Sestrin2 is known to mediate …
AMPK regulation of Raptor and TSC2 mediate metformin effects …
Oct 1, 2020 · Metformin treatment of primary hepatocytes and intact murine liver requires AMPK regulation of both RAPTOR and TSC2 to fully inhibit mTORC1, and this regulation is critical for …
AKT-mediated phosphorylation of TSC2 controls stimulus- and …
Sep 23, 2024 · While there are multiple mechanisms through which mTORC1 can sense even subtle decreases in intracellular ATP 25, the initial mechanisms involve the AMP-activated …
Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition …
Jan 7, 2017 · Here, CPT highly activates AMPK in cancer cells and significantly inhibits mTORC1 through AMPK-TSC2 axis, indicating that CPT is a natural potent AMPK activator and suitable …
AMPK/TSC2/mTOR-signaling intermediates are not necessary for …
Dec 1, 2010 · LKB1 Regulates the Nuclear-Cytoplasmic Trafficking of PTEN by Bypassing the AMPK/TSC2-Signaling Intermediates. To elucidate whether AMPK α1/2 is necessary for the …
AMPK/TSC2/mTOR pathway regulates replicative senescence of human ...
Pre-treatment of VSMCs with AMPK activator and mTOR inhibitor delayed replicative senescence and reversed changes in AMPKα, TSC2, mTOR and S6K1 phosphorylation in senescent …
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