5 days ago · Polyclonal Antibody for studying AMPK-alpha1/AMPK-alpha2. Validated for IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, AMPKα Antibody (CST #2532) is ready to ship.

1 day ago · Phospho-AMPKα (Thr172) (40H9) Rabbit mAb detects endogenous AMPKα1 only when phosphorylated at threonine 183 and endogenous AMPKα2 only when phosphorylated at threonine 172. The antibody does not detect the regulatory β or γ subunits.

5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.

Know comprehensive AMPK protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

AMP-activated protein kinase (AMPK) is a metabolic and stress-sensing kinase that regulates homeostasis, and a key target for treating Type 2 diabetes and obesity. AMPK exists as a heterotrimeric complex comprised of catalytic alpha subunits (62 kDa) and non-catalytic beta and gamma subunits.

Detects human, mouse, and rat AMPK alpha 1. No cross‑reactivity with recombinant human AMPK alpha 2 is observed.

Proposed regulation of skeletal muscle size by 5’-adenosine monophosphate-activated protein kinase (AMPK). Energy stress (decreased ATP/AMP ratio; as in moderately intensive exercise) predominantly activates AMPKα2 via liver kinase B1 (LKB1), while AMPKα1 is only activated by highly-intense or prolonged exercise.