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The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet -derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1.

The AKT1 gene provides instructions for making a protein called AKT1 kinase. This protein is found in various cell types throughout the body, where it plays a critical role in many signaling pathways.

Akt1, a serine/threonine kinase, is a multi-functional protein implicated in regulation of cell growth, survival and proliferation. Though it has a role in G1/S progression, the manner by which Akt1 controls cell cycle and blends cell growth with proliferation is not well explored.

Mar 30, 2025 · AKT1, also referred to as protein kinase B, is a known oncogene. AKT activation relies on the PI3K pathway, and is recognized as a critical node in the pathway. The E17 hotspot is the most characterized of AKT1 mutations, and has been shown to …

Aug 3, 2010 · AKT1 (NP_005154.2) is a member of the serine/threonine AGC protein kinase family involved in cellular metabolism, growth, proliferation and survival. The three human AKT isozymes are highly homologous multi-domain proteins with …

Mar 26, 2025 · Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery.

Feb 26, 2025 · AKT1, a serine/threonine kinase, is pivotal in signaling and regulating cell survival, proliferation, and metabolism. This review focuses on the structural insights and the essential features required for its active conformation.

Akt, also known as Protein kinase B (PKB), is a serine-threonine kinase with important roles in proliferation, metabolism, cell differentiation, survival, etc (1, 2). There are three distinct Akt isoforms encoded by three separate genes, namely Akt1/PKBα, Akt2/PKBβ and Akt3/PKBγ.

Feb 19, 2025 · Clinical resource with information about AKT1, Colorectal cancer, Cowden syndrome 6, Discovery and refinement of loci associated with lipid levels., Familial cancer of breast, Ovarian cancer, Proteus syndrome, and available tests.