A systematic review of the role of renin angiotensin aldosterone …
The renin angiotensin aldosterone system (RAAS) plays a vital role in regulating glucose metabolism and blood pressure, electrolyte and fluid homeostasis. The aim of this systematic …
Genetic Polymorphism in Angiotensinogen and Its Association …
The enzymes from RAAS (including AGT) play a vital role in the regulation and control of blood pressure through vasoconstriction and sodium homeostasis. AGT not only produces systemic …
The renin-angiotensin-aldosterone system: An old tree sprouts …
Dec 1, 2024 · RAAS inhibitors like ACEI and ARB, first-line treatments for acute and chronic kidney disease (CKD), lower blood pressure, reduce intrarenal pressure, decrease proteinuria, …
Analysis of renin-angiotensin aldosterone system gene …
Feb 25, 2009 · The aim of this study was to determine the association of five genetic polymorphisms (A6G and A20C of angiotensinogen (AGT), MboI of renin, Gly460Trp of …
Antisense Inhibition of Angiotensinogen With IONIS-AGT-L
Jun 1, 2021 · Targeting the top of the RAAS pathway by silencing liver-derived angiotensinogen (AGT) is a novel mechanism for RAAS inhibition. This approach has 2 potential advantages …
Role and Mechanism of the Renin-Angiotensin-Aldosterone …
The renin-angiotensin-aldosterone system (RAAS) is an important humoral regulatory system of the body that exists widely in various tissues and organs. As a compensatory mechanism, the …
Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT ...
Feb 27, 2024 · To date, the association between RAAS-associated SNPs and preeclamptic women co-morbid with HIV in South Africa has revealed that certain alleles of the AGT gene …
An antisense oligonucleotide to target the RAAS - Nature
May 26, 2021 · Inhibiting angiotensinogen (AGT) with an antisense oligonucleotide (ASO) might be a promising approach to inhibit the renin–angiotensin–aldosterone system (RAAS) for the …
Regulation and Functions of the Renin-Angiotensin System in …
Sep 9, 2017 · The renin angiotensin system (RAS) is a major regulator of blood pressure, fluid, and electrolyte homeostasis. RAS precursor angiotensinogen (Agt) is cleaved into angiotensin …
Genetic associations between genes in the renin-angiotensin ... - PubMed
May 1, 2019 · RAAS blockade, using drugs targeting individual RAAS mediators and receptors, has proven to be renoprotective. Objectives: To assess genomic variants present within RAAS …