
ADAMTS13 - Wikipedia
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing …
The role of ADAMTS13 testing in the diagnosis and management …
Aug 30, 2018 · ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) is a metalloprotease responsible for cleavage of ultra-large von Willebrand factor …
Von Willebrand Factor and ADAMTS13 | Arteriosclerosis, …
Dec 1, 2016 · The activity of VWF is modulated by ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motif repeats 13), a metalloprotease that cleaves highly procoagulant, …
ADAMTS13 and von Willebrand Factor in Thrombotic …
ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascular …
ADAMTS‐13 and von Willebrand factor: a dynamic duo - PMC
They have shown that unfolded, activated ADAMTS‐13 (GoF ADAMTS‐13, the truncated variant MDTCS and WT ADAMTS‐13 activated by VWF D4‐CK) can directly cleave the Aα chain of …
ADAMTS13 and von Willebrand factor interactions - PMC
ADAMTS13 is a zinc-containing metalloprotease that cleaves von Willebrand factor (VWF). Deficiency of plasma ADAMTS13 activity is accountable for a potentially fatal blood disorder …
ADAMTS-13 and von Willebrand factor: a dynamic duo
Recently, it has been shown that ADAMTS-13 undergoes a conformational change upon interaction with VWF, and that this enhances its activity towards its substrate. This review …
von Willebrand factor, ADAMTS-13, and thrombospondin 1 in …
Apr 23, 2023 · Low ADAMTS-13 and high VWF have been associated with cardiovascular disease and atrial fibrillation (AF). We aimed to investigate whether VWF, ADAMTS-13, and …
VWF-ADAMTS13 imbalance bridges infection to stroke
Mar 14, 2025 · The authors report that VWF deficiency reduced the severity of ischemic stroke, whereas ADAMTS13 deficiency exacerbated it, demonstrating the role of hyperadhesive VWF …
ADAMTS13: more than a regulator of thrombosis
Oct 1, 2016 · ADAMTS13 is primarily synthesized by hepatic stellate cells (HSCs), and mainly regulates thrombogenesis by cleaving VWF. Recent studies demonstrate that ADAMTS13 …