Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene. [5][6] This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family.

Mar 30, 2025 · ADAM33 (ADAM Metallopeptidase Domain 33) is a Protein Coding gene. Diseases associated with ADAM33 include Childhood-Onset Asthma and Asthma. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function. Gene Ontology (GO) annotations related to …

We highlight its genetic variants associated with asthma susceptibility and severity, as well as the functional effects of ADAM33 on airway remodeling, smooth muscle cell proliferation, and its interplay with environmental factors. Additionally, we discuss the potential clinical implications of ADAM33 as a therapeutic target for asthma management.

Jan 4, 2025 · ADAM33 gene polymorphisms serve as genetic risk factors for asthma in Indian adult population; ADAM33 gene polymorphisms may modify individual susceptibility to develop childhood asthma in the Indian population.

The identification of ADAM33 (ADAM metallopeptidase domain 33, a disintegrin and metalloproteinase domain 33) as the first novel asthma gene has implications for the mechanisms of airway hyper-responsiveness and airway wall remodeling.

ADAM 33 is a disintegrin and metalloproteinase glycoprotein 11 involved in intercellular and cell-matrix interactions and plays an important role in both health and disease.

The identification of ADAM33 on chromosome 20p13 from positional cloning as a novel candidate gene involved in the pathogenesis of these structural and functional changes has opened the way to further insight into these processes that contribute to corticosteroid refractoriness.

Mar 5, 2024 · Title: The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD. Signatures for chronic obstructive pulmonary disease (COPD) and asthma: a …

Feb 15, 2024 · Many genes have been identified as associated with asthma but none with such substantial significance as the ADAM33 gene due to its role in airway remodeling and bronchial hyperresponsiveness. This review summarizes the current knowledge on the genetic and functional aspects of ADAM33 in asthma pathogenesis.

Studies of the genetic basis of asthma have identified the ADAM33 (a disintegrase and metalloproteinase 33) gene, a novel member of the ADAM family of zinc-dependent metalloproteases, as a risk factor for the development of asthma and bronchial hyperresponsiveness (BHR).