Jul 27, 2011 · Phosphorylation at Thr-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding (By similarity). Ubiquitously expressed. Expressed at highest levels in heart, liver, skeletal muscle, kidney and testes. Expressed at lower levels in brain, spleen and lung.

A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases, activated by substrate presentation.

Dec 10, 2024 · ADAM17 is involved in both activation and HIV-1 replication in primary quiescent CD4+ T lymphocytes treated with exosomes from cells infected by HIV-1, but not by delta-Nef HIV-1 or Nef (62EEEE/AAAA65) HIV-1 strains

Gene targeting of Adam17 is embryonic lethal, highlighting the importance of ectodomain shedding during development. Tissue-specific deletion, or hypomorphic knock-in, of Adam17 demonstrates an in vivo role for ADAM17 in controlling inflammation and tissue regeneration.

Nov 16, 2022 · Herein, we summarized and updated multiple regulatory roles of ADAM17 as well as the development of ADAM17 inhibitors with a focus on the immunomodulatory role of ADAM17 in tumor development, which may provide reasonable insights for the prevention and treatment of cancer diseases.

Oct 12, 2016 · We found that ADAM17 is constitutively internalised by clathrin-coated pits and that physiological stimulators such as GPCR ligands induce ADAM17-mediated shedding, but do not alter the...

A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-a converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface proteins, such as cytokines (e.g. TNFa), cytokine receptors (e.g. IL-6R and TNF-R), ligands of ErbB (e.g. TGFa and amphiregulin) and adhesion proteins (e.g. L-selectin and ICAM-1).

Nov 30, 2023 · These results identify a role for NOX1/ADAM17 in soluble MCAM generation, with potential clinical therapeutic relevance to the aggressive, angiogenic CMS4 colorectal cancer subtype. Keywords: NADPH oxidases; angiogenesis; bioinformatic analysis; colorectal tumor; lymphangiogenesis; melanoma cell adhesion molecule; pharmacologic inhibitors.

Jul 13, 2011 · ADAM17 modulates inflammation by activation of TNFR- and IL-6R-mediated signal transduction. Therefore, ADAM17 activation is considered a pro-inflammatory event. ADAM17 mediates shedding of ErbB ligands and Notch-1 and thus potentially contributes to tissue regeneration.

ADAM17 is a prognostic marker in Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma