- Studies of ABL1 K357
Role of ABL Family Kinases in Cancer: from Leukemia to …
The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration, and invasion. ABL1 was first identified as an …
Evolution of BCR/ABL Gene Mutation in CML Is Time Dependent …
Jan 28, 2015 · Mutations in the ABL kinase domain and SH3-SH2 domain of the BCR/ABL gene and amplification of the Philadelphia chromosome are the two important BCR/ABL dependent …
- Author: Shantashri Vaidya, Babu Rao Vundinti, Chandrakala Shanmukhaiah, Prantar Chakrabarti, Kanjaksha Ghosh
- DOI: 10.1371/journal.pone.0114828
- Publish Year: 2015
- Publication: PLoS One. 2015; 10(1): e0114828.
Tyrosine kinase inhibitor response of ABL-class acute …
May 23, 2024 · The BCR::ABL1-positive subtype and ABL-class subtype, each accounting for ∼3% of newly diagnosed pediatric ALL cases, involve fusions with ABL family tyrosine kinase genes. 1 In this study, the ABL-class subtype was …
Asciminib is safe and effective in patients with newly ... - Nature
Jun 25, 2024 · Four BCR–ABL1 tyrosine-kinase inhibitors (TKIs) are approved for patients with newly diagnosed chronic myeloid leukaemia (CML): the first-generation agent imatinib and …
Introduction: The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs imatinib mesylate (IM) binding capacity, thus contributing to IM resistance. Identification of these …
ABL1 K357dup: Gene Variant Detail - Cancer Knowledgebase (CKB)
ABL1 K357dup indicates the insertion of the duplicate amino acid, lysine (K)-357, in the protein kinase domain of the Abl1 protein (UniProt.org).
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Clinical Insights into Structure, Regulation, and Targeting of ABL ...
Mar 14, 2024 · In this article, we systemically review the structural and molecular properties of the critical domains of BCR::ABL1 and how understanding the essential role of BCR::ABL1 kinase …
Dynamic Changes in ABL1 Kinase Domain Mutations and …
Nov 2, 2023 · Testing BCR-ABL1 KD mutations in early phase accurately is of great value in predicting response and guiding therapeutic decisions. Next-generation sequencing (NGS) …
Sep 14, 2010 · ABL1 includes nuclear localization signals and a DNA bind-ing domain through which it mediates DNA damage-repair functions, whereas ABL2 has additional binding …
Pathogenic variants causing ABL1 malformation syndrome cluster …
Nov 22, 2020 · ABL1 is a proto-oncogene encoding a nonreceptor tyrosine kinase, best known in the somatic BCR-ABL fusion gene associated with chronic myeloid leukaemia. Recently, …
