The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response such as DNA repair.

A genetic rearrangement (translocation) involving the ABL1 gene causes a type of cancer of blood-forming cells called chronic myeloid leukemia. This slow-growing cancer leads to an overproduction of abnormal white blood cells.

Mar 28, 2025 · ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ABL1 include Congenital Heart Defects And Skeletal Malformations Syndrome and Leukemia, Chronic Myeloid.

Gene ID: 25, updated on 20-Feb-2025. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress.

The ABL1 gene provides instructions for making a protein involved in many processes in cells throughout the body. The ABL1 protein functions as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. The ABL1 kinase is

The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration, and invasion. ABL1 was first identified as an oncogene required ...

The Abl family of cytoplasmic tyrosine kinases consists of 2 members, Abl and Arg (Abl-related gene), encoded by the ABL1 and ABL2 genes in humans, and has important roles in various biological processes. 1,2 Abl kinases share a central SH2-kinase domain unit with the majority of other cytoplasmic kinases 3 and have a long C-terminal tail ...

Apr 7, 2025 · Depression accelerates the development of gastric cancer through reactive oxygen species‑activated ABL1 (Review). Huang T, et al. Oncol Rep, 2016 Nov. PMID 27666407. What's a GeneRIF? VNTR polymorphism in the breakpoint region of …

Nov 22, 2020 · Recently, germline missense variants in ABL1 have been found to cause an autosomal dominant developmental syndrome with congenital heart disease, skeletal malformations and characteristic facies.

Apr 9, 2025 · BCR::ABL1 in the general population mirrored CML incidence, and advanced and/or blast phase CML was characterized by subsequent genomic evolution. These data highlight the oncogenic potency of BCR ...