When constructing an AAV transfer plasmid, the transgene is placed between the two ITRs, and Rep and Cap are supplied in trans. In addition to Rep and Cap, AAV requires a helper plasmid …

AAV serotype 8 (AAV8) shows a significantly greater liver transduction efficiency than those of other serotypes, which has resulted in efforts to develop this virus as a gene therapy vector for …

Adenoviruses and Adeno-Associated Viruses (AAVs) are two types of viral vectors used for gene delivery. Both of these recombinant viral systems have the ability to infect a broad range of …

Jan 29, 2025 · AAV-LK03 transduced hepatocytes much more efficiently and specifically than AAV5, AAV8 and AAV6, which are most commonly used clinically, and AAV-NP59, which is …

Jan 12, 2024 · Research has indicated that AAV8 and AAV9 exhibit a notable affinity for liver cells, with AAV8 demonstrating the highest degree of hepatophilia. rAAV8 can transfect …

Jan 1, 2024 · AAV8 vectors are valued for their high hepatophilic effect and relatively low immunogenicity. Pre-existing immunity is a major challenge for gene therapy, and these pre …

Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat

AAV8 and AAV9 are superior to AAV2 for liver transduction, and AAV-DJ was on par with AAV8/9 in vivo liver expression . Gene therapy may require multiple doses, and an immune response …

Feb 27, 2005 · We show that AAV8 is the most efficient vector for crossing the blood vessel barrier to attain systemic gene transfer in both skeletal and cardiac muscles of mice and …

Here we analyze the tropism of 10 naturally occurring AAV serotypes (AAV3B, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAVrh8, AAVrh10, and AAVrh74) following systemic delivery into …