Human OAS1 activation is highly dependent on both RNA …
Jul 27, 2020 · Both in vitro and in human A549 cells, appending a 3'-end single-stranded pyrimidine (3'-ssPy) can strongly enhance OAS1 activation or have no effect depending on its …
- Author: Samantha L Schwartz, Esther N Park, Virginia K Vachon, Shamika Danzy, Anice C Lowen, Graeme L Conn
- Publish Year: 2020
See results only from pubmed.ncbi.nlm.nih.govIn silico identification of pote…
In this study, we have used homology modeling and virtual high-throughput …
Characteristics of Human OA…
The human OAS1 (hOAS1) gene produces multiple possible isoforms due to …
Endomembrane targeting of …
Membrane localization of OAS1 p46 confers enhanced access to viral replication …
Genetic regulation of OAS1 n…
We demonstrate that two exonic variants, rs10774671 and rs1131454, affect …
Differential Responses by Human Respiratory Epithelial …
We show that A549 cells are permissive to RSV infection and express genes characteristic of a proinflammatory response. In contrast, BEAS-2B cells restrict infection and express genes characteristic of an antiviral response associated …
Characteristics of Human OAS1 Isoform Proteins - PMC
The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 …
Endomembrane targeting of human OAS1 p46 augments antiviral …
Aug 3, 2021 · Membrane localization of OAS1 p46 confers enhanced access to viral replication sites and results in increased antiviral activity against a subset of RNA viruses including …
- Author: Frank W Soveg, Johannes Schwerk, Nandan S Gokhale, Karen Cerosaletti, Julian R Smith, Erola Pairo-Ca...
- DOI: 10.7554/eLife.71047
- Publish Year: 2021
- Publication: eLife. 2021; 10: e71047.
OAS cross-activates RNase L intercellularly through cell …
Apr 8, 2025 · A549-A76V cells were co-cultured with increasing amounts of wild-type MEF cells (ratios ranging from 1:8 to 1:0.25 MEF:A549-A76V) overnight (n = 3). A549-A76V cells are RNASEL KO A549 cells expressing human OAS1 …
A human cellular noncoding RNA activates the antiviral protein …
Oct 12, 2018 · Here, we demonstrate that the human cellular noncoding RNA 886 (nc886) activates OAS1 both in vitro and in human A549 cells. We show that a unique structure …
- People also ask
Feb 25, 2025 · The human OAS1-A76V mutant synthesizes 2-5A indepen-dently of dsRNA binding and is associated with severe autoin-flammatory disease.5 We first confirmed that …
OAS/RNase L pathway activation in A549 cells by the short …
OAS1 is a sensor of endogenous RNA that triggers the 2'-5' oligoadenylate/RNase L pathway in response to viral infections, ultimately activating the RNA-Lyase which cleaves endogenous …
Genetic regulation of OAS1 nonsense-mediated decay underlies ...
Jul 9, 2021 · We demonstrate that two exonic variants, rs10774671 and rs1131454, affect splicing and nonsense-mediated decay of OAS1. We suggest that genetically-regulated loss of OAS1 …
Inducible CRISPR activation screen for interferon-stimulated genes ...
Apr 14, 2022 · A549-SunTag ACE2 and A549 ΔSTAT1-SunTag ACE2 cells were transduced with expression constructs for gRNAs targeting one of eight antiviral ISG hits (CD74, LY6E, OAS1, …
Related searches for A549 OAS1