Targeting the sheddase activity of ADAM17 by an anti-ADAM17 ... - PubMed
Jun 21, 2014 · Here, we report that treating human HNSCC cells in vitro with a human anti-ADAM17 inhibitory antibody, D1 (A12), suppresses proliferation and motility in the absence or …
Targeting the Sheddase Activity of ADAM17 by an Anti-ADAM17 …
Here, we report that treating human HNSCC cells in vitro with a human anti-ADAM17 inhibitory antibody, D1 (A12), suppresses proliferation and motility in the absence or presence of the …
Recent Advances in ADAM17 Research: A Promising Target for …
Huang Y., Benaich N., Tape C., Kwok H. F., Murphy G. Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell …
Inhibitory monoclonal antibody targeting ADAM17 expressed on …
Nov 9, 2021 · Huang Y., Benaich N., Tape C., Kwok H.F., Murphy G. Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1 (A12) inhibits head and neck squamous …
Strategies to Target ADAM17 in Disease: From Its Discovery to …
This approach allowed the isolation of an ADAM17 cross-domain inhibitory antibody, called D1(A12), which is a fivefold better inhibitor than TIMP-3 in blocking ADAM17-dependent …
Anti-tumour effects of a specific anti-ADAM17 antibody in an ... - PubMed
D1(A12) IgG showed a significant reduction in tumour growth (p = 0.005), 56% of vehicle control. Surprisingly, D1(A12) did not reduce the concentration of circulating human TNF-α, suggesting …
Functionally confirmed compound heterozygous ADAM17 missense …
May 5, 2021 · In a cell-based assay using Adam10/17 double-knockout mouse embryonic fibroblasts (Adam10 / 17−/− mEFs) exogenously expressing each of these mutants, phorbol …
Targeting ADAM-17 with an inhibitory monoclonal antibody has ... - PubMed
Jun 9, 2015 · Results: D1(A12) was found to significantly inhibit the release of TGFα, and to decrease downstream EGFR-dependent cell signalling. D1(A12) treatment reduced …
Savior or not: ADAM17 inhibitors overcome radiotherapy …
Recent studies reported that anti-ADAM17 D1(A12) monoclonal antibody, the first specific inhibitor for ADAM17, showed anti-tumor effect in vitro and in vivo (15,16). This monoclonal …
Targeting the Sheddase Activity of ADAM17 by an Anti-ADAM17 …
Jun 21, 2014 · Here, we report that treating human HNSCC cells in vitro with a human anti-ADAM17 inhibitory antibody, D1 (A12), suppresses proliferation and motility in the absence or …