In molecular biology 7SK is an abundant small nuclear RNA found in metazoans. [1] It plays a role in regulating transcription by controlling the positive transcription elongation factor P-TEFb. [2] 7SK is found in a small nuclear ribonucleoprotein complex (snRNP) with a number of other proteins that regulate the stability and function of the ...

The human 7SK small nuclear RNA (snRNA) is an abundant noncoding RNA whose function has been conserved in evolution from invertebrates to humans. It is transcribed by RNA polymerase III (RNAPIII) and is located in the nucleus.

Mar 30, 2025 · RN7SK (RNA Component Of 7SK Nuclear Ribonucleoprotein) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with RN7SK include Acquired Immunodeficiency Syndrome and Immune Deficiency Disease. ... Cas9 Proteins, Cas9 Nuclease Vector/Virus, Cas9-Expressing Cell Lines also available.

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA ...

Sep 17, 2013 · The non-coding RNA (ncRNA) 7SK has a central role in controlling transcription in embryonic stem cells. 7SK is required for the repression of genes that are silent or expressed at a low level. Widespread failed transcriptional termination was also seen after 7SK knockdown.

Feb 24, 2021 · The noncoding RNA 7SK controls the transcription of mRNAs. Here, the authors show that the 7SK complex interacts with the Smn complex, suggesting crosstalk between transcription and snRNP...

Oct 10, 2023 · We find that 7SK small nuclear RNA (snRNA), a regulator of RNA Pol II promoter-proximal pausing, is highly m 6 A-modified in non-small cell lung cancer (NSCLC) cells.

Mar 8, 2025 · Title: 7SK small nuclear RNA (Rn7SK) induces apoptosis through intrinsic and extrinsic pathways in human embryonic kidney cell line. A positive feedback circuit between RN7SK snRNA and m[6]A readers is essential for tumorigenesis.

Oct 7, 2021 · Here, we deplete RN7SK during mouse and human epidermal stem cell differentiation. Unexpectedly, loss of this small nuclear RNA specifically reduces transcription of numerous cell cycle...

7SK is a small nuclear RNA (snRNA) about 330 nucleotides (nt) in length. The 3′ end of 7SK RNA binds strongly to LARP7/PIP7S to form snRNP, which may prevent 7SK RNA from degradation (Bayfield et al., 2010).