Studies demonstrating that abrogation of MUC4 expression reduces proliferation and metastasis of PC cells and enhances sensitivity to therapeutic agents affirm its utility as a therapeutic …

With both 6E8 and E9 antibodies, it was shown that the released protein maintained over 90% antigenic reactivity compared to control MUC4β. As a negative control, the anti-MUC4α …

MUC-4 has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. …

MUC4 is putatively cleaved at the GDPH site into a mucin-like α-subunit and a membrane-tethered growth factor-like β-subunit. Due to the presence of several functional domains, the …

Jun 26, 2007 · To understand the precise role of MUC4 in pancreatic cancer, we engineered a MUC4 complementary DNA construct, mini-MUC4, whose deduced protein (320 kDa) is …

Dec 9, 2021 · We developed a method to produce and purify multi-milligram amounts of recombinant MUC4β (rMUC4β). Purified rMUC4β was characterized by Far-UV CD and I …

Jul 1, 2018 · Our results suggested that these antibodies can potentially block MUC4 function. The mAbs, 3B4, 1C7 and 6E8 inhibited the growth of MUC4 expressing cells in MTT and …

The dysregulation of MUC4 expression, often dramatic, together with the homology to SMC/r Muc4, which is considered to promote tumor cell metastasis (24), points out an important role …

MUC4 is putatively cleaved at the GDPH site to generate an N-terminal mucin-type subunit MUC4-a and a C-terminal growth factor-type subunit MUC4-b. Important domains of MUC4 …

Dec 9, 2021 · We developed a method to produce and purify multi-milligram amounts of recombinant MUC4β (rMUC4β). Purified rMUC4β was characterized by Far-UV CD and I …