The 5-HT 2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [1] The 5-HT 2 subfamily consists of three G protein-coupled receptors (GPCRs) which are coupled to G q /G 11 and mediate excitatory neurotransmission, [2] including 5-HT 2A, 5-HT 2B, and 5-HT 2C. For more ...

5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [1][2][3] They mediate both excitatory and inhibitory neurotransmission.

5-hydroxytryptamine (5-HT) has become one of the most investigated and complex biogenic amines. The main receptors and their subtypes, e.g., 5-HTI (5-HT1A, 5-HT1B, 5-HTID, 5-HTIE and 5-HT1F), 5-HT2 (5-HT2A, 5-HT2B and 5-HT2C), 5-HT3, 5-HT4, 5-HT5 (5-HT5A, 5-HT5B), 5-HT6 and 5-HT7 have been identified.

Like all 5-HT 2 receptors, the 5-HT 2A receptor is G q /G 11 -protein coupled. This is the main excitatory receptor subtype among the GPCRs for serotonin. This receptor was first noted for its importance as a target of serotonergic psychedelic drugs such as …

In this review, a search was conducted on PubMed, ProQuest, EBSCO, and the Science Citation Index for studies evaluating the effects of 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the CNS on the modulation of different types of pain.

This compilation of research and review articles presents contemporary perspectives dedicated to serotonin (5-HT) 5-HT 2C receptor (5-HT 2C R) and its pharmacological targeting. The volume also covers the impact of disease conditions or treatments on 5-HT 2C R expression and function in preclinical models of human pathologies.

The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subty …

The 5-HT 2 receptor family (5-HT 2A, 5-HT 2B, and 5-HT 2C), are postsynaptic receptors associated with fine serotonergic fibers throughout cerebral cortical areas including the cingulate, frontal, temporal, and occipital cortices (Jacobs and Azmitia 1992).

Nov 29, 2024 · Understanding neuromodulatory effects of serotonin 2A receptor (5-HT 2A R) agonists with diverse pharmacological profiles is relevant to advancing psychedelic-related drug applications.

Aug 19, 2003 · Overexpressing serotonin Gq–coupled 5-HT 2B receptor in the mouse heart induces mitochondrial proliferation associated with hypertrophy, whereas ablation of this receptor leads to mitochondrial structural and functional impairments associated with myofibrillar breakdown and dilated cardiomyopathy.