Sep 24, 2021 · Our results showed that the combination of oncolytic adenoviruses with anti-programmed cell death-ligand 1 (anti-PD-L1) and anti-cytotoxic T lymphocyte-associated antigen-4 (anti-CTLA-4) (aPC)...

Aug 8, 2021 · Here, a novel strategy to selectively degrade membrane proteins of programmed cell death-ligand 1 (PD-L1) in cancer cells is reported. 4T1 cells show high levels of extracellular alkaline phosphatase (ALP) and membrane proteins of PD-L1.

Oct 27, 2020 · Here, using multiple orthotopic tumor mouse models resistant to anti-PD-L1-therapy, we are testing the hypothesis that in situ induction and activation of tumor-residing cDC1s overcomes...

Nov 15, 2024 · In this study, we presented a biorthogonal click strategy for tumor-specific PD-L1 inhibition and boosting antitumor immunity. This strategy involves efficient PD-L1 blockade via covalent binding of the small-molecule inhibitors to PD-L1 on the surface of tumor cell membrane via click reaction.

Oct 25, 2019 · We load both a near-infrared (NIR) photothermal agent IR820 and a programmed death-ligand 1 antibody (aPD-L1) into a lipid gel depot with a favorable property of thermally reversible gel-to-sol...

Feb 6, 2025 · Immune checkpoint blockade (ICB) therapy, targeting programmed cell death ligand-1 (PD-L1)/programmed cell death protein 1 (PD-1) axis and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), has exhibited amazing clinical outcomes in …

5 days ago · For the analysis of PD-L1 expression and PD-1/PD-L1 blockade on DCs. Culture medium of 4T1 cells after culturing for 48 h was collected first and mixed with DMEM (with 10% FBS) at a ratio of 1:1. DC2.4 cells were seeded in 6-well plates for attachment. Some of the wells were treated with the mixed medium above and incubated for 24 h.

Nov 27, 2024 · These LNPs, termed piLNPs, are encapsulated with indocyanine green and incorporated with the antigen (Ag)-binding fragment of the anti-PD-L1 antibody for targeting tumors and immunotherapy. Intravenously injected piLNPs in 4T1 breast tumor-bearing BALB/c mice effectively target the 4T1 tumor and are suitable for performing PTT using a near ...

Mar 5, 2025 · RT plus YM101 enhances tumor suppression in multiple murine tumor models. Previous studies have suggested that either anti-PD-L1 or TGF-β blockade could synergistically enhance the antitumor effect of RT in 4T1 breast cancer model, which is known for its limited immune cell infiltration and relative resistance to ICIs [].Given the intricate nature of the TME and the complex interaction ...

Mar 31, 2025 · Cell uptake, apoptosis, and proliferation of 4T1 breast cancer cells were evaluated by flow cytometry and Resazurin assay, respectively. ... cyclophosphamide and 5-FU effects on the Circulating and intratumoural landscape of immune cells improve anti-PD-L1 efficacy in preclinical models of breast cancer and lymphoma. ... Rose PD, Jesudason S ...