Nov 23, 2023 · Introducing additional binding arms to DNA crossover tiles holds the promise of unlocking diverse nano-assemblies and potential applications. Here, we present one-, two-, and three-layer...

There are numerous ways to fabricate DNA tiles suitable for constructing lattices. Though, there are two distinguishable classes of DNA-tile structures: DNA motifs and DNA origami units, which both can serve as building blocks, i.e., tiles .

May 30, 2012 · Complex, self-assembling, two-dimensional nanostructures can be built of single-stranded DNA tiles by a method that allows individual control of more than one thousand distinct components.

Jun 15, 2022 · Formation of coupled double crossovers (DXs) in a circular 106-mer oligonucleotide (c106nt) could generate stable tiles with the tile core span of 10 half turns. The large-span tiles with complicated curvatures and mechanics could assemble 2D lattices under different environments.

Mar 1, 2016 · Tile-based self-assembly and DNA origami are directed by the specificity of binding and predictability of canonical Watson–Crick base pairing. This review discusses the design and use of various DNA tiles in the hierarchical self-assembly of two- …

Mar 24, 2024 · In this study, we present two approaches to direct the linear growth and 2D self-assembly of DNA tiles. The first strategy involves using toehold-mediated strand-displacement reactions. The second approach employs a photoresponsive duplex module, which contains a tile-activator strand coupled with a complementary strand that incorporates a ...

Aug 23, 2019 · Various groups have successfully used 2D DNA lattices built from DNA tiles to construct periodic protein arrays by placing them either directly on the DNA or by using the DNA lattice as a mask (Figure 6A) [35,124–126]. Moreover, these tiles are easily programmable to form a variety of different sophisticated arrays that could serve as masks ...

Mar 10, 2021 · This review first summarizes currently available DNA tile toolboxes and the basic principles of lattice formation and hierarchical self-assembly using DNA tiles. Special emphasis is given to the forces involved in the assembly process in liquid-liquid and at solid-liquid interfaces, and how to master them to reach the optimum balance between ...

Jun 15, 2022 · Four types of tiles, two rectilinear and two triangular tiles, were designed and their 2D assemblies were examined by atomic force microscopy (AFM). Findings: The DX-coupled tiles provided fair strength and rigidity to assemble 2D lattices.

Nov 23, 2023 · Introducing additional binding arms to DNA crossover tiles holds the promise of unlocking diverse nano-assemblies and potential applications. Here, we present one-, two-, and three-layer T-shaped crossover tiles, by integrating T junction with antiparallel crossover tiles.