2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP 3 receptors [1] and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).

Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation of Ca2+ signals.

A cell-permeable modulator of Ins(1,4,5)P 3-induced Ca 2+ release. Inhibits Ins(1,4,5)P 3-induced Ca 2+ release from rat cerebellar microsomal preparations (IC 50 = 42 µM) without affecting [3 H]-Ins(1,4,5)P 3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca 2+ channels through a mechanism which may involve its binding to either the channel protein or an associated ...

Aldrich-D9754; 2-Aminoethyl diphenylborinate; CAS No.: 524-95-8; Linear Formula: (C6H5)2BOCH2CH2NH2; Empirical Formula: C14H16BNO; find related products, papers, technical documents, MSDS & more at Sigma-Aldrich.

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3).

2-Aminoethyl diphenylborinate. (C6H5)2BOCH2CH2NH2. Synonyms: 2-APB, 2-Aminoethoxydiphenyl borate, 2-Aminoethyl diphenyl borate, Diphenylboric acid 2-aminoethyl ester, Diphenylborinic acid, NSC 17107. CAS 524-95-8. Molecular Weight 225.09. Browse 2-Aminoethyl diphenylborinate and related products at MilliporeSigma.

Sep 1, 2012 · 2-Aminoethyl diphenyl borinate (2-APB) is a membrane-permeant, lipophilic compound that was originally described as a blocker of intracellular inositol 1,4,5 trisphosphate [Ins (1,4,5) P3] receptors. 1, 2 Soon afterwards, it was discovered that this compound can block store-operated calcium channels in various cell types without engaging the Ins...

Mar 2, 2020 · In this study we report that 2-aminoethoxydiphenylborate (2-APB) significantly inhibits the release of PS-exposing EVs from platelets stimulated with the Ca 2+ ionophore, A23187, or the...

Feb 8, 2023 · 2-APB, a TRP channel blocker inhibitor reversed mitochondrial dysfunctions seen in PD. 2-APB was further observed to work by inhibiting oxidative stress which increased cell viability in MPP+ -treated SH-SY5Y cells. 2-APB also restored the tyrosine hydroxylase levels in the striatum and midbrain, areas affected in PD.