CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and …
Cytotoxic CD8 + T cells in cancer and cancer immunotherapy
Sep 15, 2020 · New generations of cytotoxic T cells with genetically modified or synthetic receptors are being developed and evaluated in clinical trials. Furthermore, combinatory …
A distinct priming phase regulates CD8 T cell immunity by ... - AAAS
As CD8 T cells underwent a second phase of stable interactions with DCs, helper CD4 T cells halted briefly before moving on to another DC, whereas regulatory T cells did not stop. This …
The diversity of CD8 + T cell dysfunction in cancer and viral infection
5 days ago · Defective immunity can arise in two conceptually distinct scenarios: first, failed or suboptimal CD8 + T cell priming, resulting in anergy (Fig. 1 and Box 1), and second, …
Cytokines and the Inception of CD8 T Cell Responses - PMC
In this article we discuss how inflammatory cytokines and IL-2 bias the initial response towards short-lived effector generation and also highlight the potential counterbalancing role of IL-21.
Cytotoxic T Cell Overview | Thermo Fisher Scientific - US
What are cytotoxic T cells? Cytotoxic T lymphocytes (CTLs) often called CD8 + T cells, are a critical component of the adaptive immune system and play an important role in immune …
The diversity of CD8 + T cell dysfunction in cancer and viral
CD8 + T cells that are repeatedly exposed to antigenic stimulation, such as in the context of progressing neoplasms and chronic viral infections, acquire a dysfunctional or hypofunctional …
Single-cell transcriptomic analysis reveals CD8 + T cell …
Mar 18, 2025 · CD8 + T cell subsets interact with macrophages through different ligand-receptor networks, including the CCL-CCR signaling pathway and costimulatory molecules. Sorafenib …
CD8 Activation Markers and Their Role in T-Cell Function
Mar 20, 2025 · Explore the role of CD8 activation markers in T-cell function, their expression across tissues, and methods for assessing immune responses in different contexts. CD8 T …
CD8 - Wikipedia
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell …