Jan 11, 2025 · MMP1 gene expression; BioGPS; BioGPS; BioGRID Open Repository of CRISPR Screens (ORCS) BioGRID CRISPR Screen Phenotypes (9 hits/1278 screens) Eukaryotic Promoter Database; MMP1_1; GlyGen glycoinformatics resource; GlyGen glycoinformatics resource; Guide to Pharmacology; MMP1 gene; Human Gene Mutation Database; Human …

Feb 8, 2025 · MMP1 gene expression; BioGPS; BioGPS; BioGRID Open Repository of CRISPR Screens (ORCS) BioGRID CRISPR Screen Phenotypes (12 hits/1376 screens) Eukaryotic Promoter Database; MMP1_1; GlyGen glycoinformatics resource; GlyGen glycoinformatics resource; Guide to Pharmacology; MMP1 gene;

Since the initial discovery of MMP1 over 50 years ago in tadpoles, the matrix metalloprotease family has expanded to 24 enzymes in humans with a multitude of functions (Gross and Lapiere, 1962).MMP1 (interstitial collagenase) was initially described for its ability to degrade fibrillar collagen (types I, II, and III) with the subsequent identification of two similar enzymes, MMP8 …

Aug 10, 2022 · Matrix metalloproteinase 1 (MMP1) encodes endopeptidases associated with degradation of multiple components of the extracellular matrix. This function has increasingly been considered to play a major proteolysis role in tumor invasion and metastasis. However, the relationship between MMP1 gene expre …

MMP1 is a gene that drives breast cancer cells to become tamR. During the induction of tam resistance, the MMP1 gene is upregulated through hypomethylation at its promoter. Suppressing MMP1 expression attenuates tam resistance and increases apoptosis, as confirmed by in vitro cell culture and an in vivo xenograft mouse model.

Sep 14, 2016 · Gene target information for MMP1 - matrix metallopeptidase 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Oct 13, 2023 · The expression of MMP1 gene is mediated by numerous factors, including polymorphisms which act as a potential risk factor for the progression of breast cancer. To establish the correlation between genetic polymorphisms in MMP1 and the risk of breast cancer, several case-control studies, as well as genetic analyses, have been carried out in ...

The review aims to shed light on the potential role of MMP1 gene polymorphisms in BC by discussing their association with BC risk. It also delves into the structure of the MMP1 and explores its potential role in the development and progression of BC.

The matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that play a key role in both physiological and pathological tissue remodeling. Human fibroblast collagenase (MMP-1) was the first vertebrate collagenase purified as a …

Matrix metalloproteinases (MMP) play a key role in the breakdown of extracellular matrix and in inflammatory processes. MMP1 is the most highly expressed interstitial collagenase degrading fibrillar collagens. Overexpression of MMP1 has been shown in tumor tissues and has been suggested to be associ …