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    Integrated view of the 'third signal' in NK cells. (1a) Recognition of tumor cells via stress-induced ligands, such as H60, provides primary activation via NKG2D in murine NK cells. (1b) Similarly, recognition of viral proteins including MCMV-derived m157 mediates stimulation of murine NK cells via ly49H. These two activation receptors mediate their signals utilizing DAP10 and DAP12. (1c) NK cells also mediate target cell recognition using antibodies bound to its receptor CD16a. The downstream signaling cascades lead to cytokine production and cytotoxicity against target cells. (2a) IL-15 produced by DCs is trans-presented to NK cells to proliferate. (2b) IL-2 from CD4 + T cells plays a similar role in the expansion of NK cells. However, the context where DCs or CD4 + T cells play this role is yet fully defined. (3a) IL-12 and Integrated view of the 'third signal' in NK cells. (1a) Recognition of tumor cells via stress-induced ligands, such
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    CD14 (cluster of differentiation 14) is a human protein primarily produced by macrophages. Its function includes:
    Wikipedia
    CD14 - Wikipedia
    CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolys…
    Wikipedia
    https://en.wikipedia.org › wiki
    Role of CD14 in human disease - Wiley Online Library
    The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in…
    wiley.com
    https://onlinelibrary.wiley.com › doi › epdf
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    All About the CD14 Marker: Function and Significance
    CD14 has long been recognized as a differentiation marker for monocytes and macrophages. This glycoprotein serves as a cell surface receptor with a critical role in bacterial recog…
    NeoBiotechnologies
    https://www.neobiotechnologies.com › resources › recombinant-monoclonal-antibodies
    What are the functions of CD14? | AAT Bioquest
    CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor that may be expressed by cells of both hematopoietic and non-hematopoietic origin as a cell membrane or secreted prot…
    AAT Bioquest
    https://www.aatbio.com › resources › faq-frequently-asked-questions
    Wikipedia
    wiley.com
    NeoBiotechnologies
    AAT Bioquest
    Wikipedia
    https://en.wikipedia.org › wiki
    CD14 - Wikipedia
    CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolys…
    wiley.com
    https://onlinelibrary.wiley.com › doi › epdf
    Role of CD14 in human disease - Wiley Online Library
    The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in…
    NeoBiotechnologies
    https://www.neobiotechnologies.com › resources › recombinant-monoclonal-antibodies
    All About the CD14 Marker: Function and Significance
    CD14 has long been recognized as a differentiation marker for monocytes and macrophages. This glycoprotein serves as a cell surface receptor with a critical role in bacterial recog…
    AAT Bioquest
    https://www.aatbio.com › resources › faq-frequently-asked-questions
    What are the functions of CD14? | AAT Bioquest
    CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor that may be expressed by cells of both hematopoietic and non-hematopoietic origin as a cell membrane or secreted prot…
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