Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. [5][6] Histones play a critical role in transcriptional regulation, cell cycle …

Among class II HDACs, HDAC4 is implicated in controlling gene expression important for diverse cellular functions. Basic and clinical experimental evidence have well established that HDAC4 …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …

HDACs are divided into three distinct classes: I, II, and III, on the basis of size and sequence homology, as well as formation of distinct complexes. Among class II HDACs, HDAC4 is …

Mar 30, 2025 · HDAC4 (Histone Deacetylase 4) is a Protein Coding gene. Diseases associated with HDAC4 include Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic …

The HDAC4 gene provides instructions for making an enzyme called histone deacetylase 4. This enzyme is part of a group of related enzymes, called histone deacetylases, that modify …

Histone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various …

HDAC4 is a target gene of miR-140 and is involved in miR-140-mediated suppression of osteosarcoma cells. HDAC4 increases endogenous SIRT1 expression by enhancing its …

Dec 10, 2024 · Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the …

We identified a specific super-enhancer region associated with HDAC4, referred to as HDAC4-SE. Among its nearby genes, TWIST2 emerged as a key player, strongly linked to …