Serine Protease, Enzyme Catalysis | Learn Science at Scitable - Nature
Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase. It is transported to ...
Serine and one-carbon metabolism in cancer - Nature
Sep 16, 2016 · Serine is a non-essential amino acid that can be taken up by the cell or synthesized de novo from glycolytic intermediates through the serine synthesis pathway (SSP). Serine is used for many ...
An epidermal serine sensing system for skin healthcare
Mar 18, 2025 · Serine is an important biomarker for skin healthcare. Here, the authors introduce a portable epidermal sensing system capable of direct sampling and in situ quantification of serine on the skin ...
The ins and outs of serine and glycine metabolism in cancer
Jan 28, 2021 · Serine and glycine synthesis (Fig. 1) consists of two processes: de novo serine synthesis from glucose and reversible interconversion of serine into glycine. De novo serine synthesis branches from ...
NAT10-mediated mRNA N4-acetylcytidine reprograms serine
Nov 6, 2024 · Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.
Revisiting the role of serine metabolism in hepatic lipogenesis
May 11, 2023 · Third, serine supplementation has been shown to attenuate HS in rodent models fed with high-fat diet or ethanol 10,11,12, and in a proof-of-concept human study 8, in which participants with high ...
Serine synthesis through PHGDH coordinates nucleotide levels by ...
Dec 21, 2018 · The serine, glycine, one-carbon network generates carbon units that satisfy many metabolic demands including nucleotide precursors for anabolic metabolism, redox maintenance, and substrates for ...
Serine protease NAL1 exerts pleiotropic functions through
Jun 22, 2023 · A Dali (a structure comparison server) search revealed that NAL1 was a serine protease according to the structural similarity (Extended Data Fig. 1e and Supplementary Table 2).Thus, each NAL1 ...
Functional profiling of serine, threonine and tyrosine sites
Sep 23, 2024 · The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible involvement in ...
Phenotypic profiling of solute carriers characterizes serine …
Dec 8, 2023 · Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine synthesis, most transformed cells rely on serine uptake to meet their increased biosynthetic requirements.