In medicinal chemistry and molecular biology, a pharmacophore is an abstract description of molecular features that are necessary for molecular recognition of a ligand by a biological …

Pharmacophore is defined as a 3D arrangement of the functional molecule, which is crucial to attach or bind to an active site of an enzyme or molecule. From: Translational Biotechnology, …

A pharmacophore is an abstract description of molecular features that are necessary for molecular recognition of a ligand by a biological macromolecule. IUPAC defines a …

Pharmacophore approaches represent one of the most interesting tools developed, by defining the molecular functional features needed for the binding of a molecule to a given receptor, and …

Apr 18, 2023 · The pharmacophore concept was first put forward as a useful picture of drug interactions almost a century ago, and with the rise in computational power over the last few …

Jan 1, 2017 · Together with QSAR (Quantitative Structure Activity Relationship) and molecular similarity analysis, the pharmacophore concept is one of the major paradigms in ligand-based …

Pharmacophore models can be derived both in a receptor-based and in a ligand-based manner, and provide an abstract description of essential non-bonded interactions that typically occur …

The analytical process and underlying principles of the pharmacophore-based drug design approach are presented and discussed. The strengths and limitations of the method are …

Sep 5, 2024 · A pharmacophore is a theoretical model that represents the essential features responsible for a drug's biological activity, including elements like hydrogen bond acceptors, …

A pharmacophore may be defined as the essential geometric arrangement of atoms or functional groups necessary to produce a given biological response. From: Guidebook on Molecular …