Hemosiderin or haemosiderin is an iron -storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [1][2] The body then traps the released iron and stores it as hemosiderin in tissues. [3]

Aug 9, 2018 · Hemosiderin — a protein compound that stores iron in your tissues — can accumulate under your skin. As a result, you may notice yellow, brown, or black staining or a bruiselike...

May 20, 2023 · Hemosiderin staining looks like a patch of skin that is a darker color than the surrounding skin. It can look like bruising, or it can be brownish or rust-colored. It may be …

Feb 21, 2025 · Hemosiderin is often associated with blood vessel conditions that lead to an excessive breakdown of iron-containing cells. The most notable condition that causes hemosiderin staining is chronic venous insufficiency (CVI).

Hemosiderin staining shows up in the lower legs as a dark purple or rusty discoloration on the skin. See what causes hemosiderin staining and how it's treated.

Feb 12, 2025 · Hemosiderin deposition is an iron storage issue related to conditions like chronic venous insufficiency, liver disease, and autoimmune disorders. You might notice symptoms like brown discoloration of the skin, similar to bruising, usually on your lower legs.

Jun 9, 2024 · Venous hypertension / insufficiency happens when high pressure in the veins in your legs causes substances from the blood to leak into your tissues. Blood is pumped from the heart to the rest of the body through the arteries and returns through the veins.

Hemosiderosis is a term used for excessive accumulation of iron deposits (called hemosiderin) in the tissues with little or no damage to organs. (See also Overview of Iron Overload.) The lungs, liver, spleen, bone marrow, and kidneys are often sites …

Hemosiderin is an insoluble form of tissue storage iron, being found at the level of different cells (not in the circulating blood). This is actually a protein that is insoluble and contains irons, being produced by the digestion of the hematin by the phagocytes.

Mar 24, 2025 · Learn about hemosiderin staining, its causes like chronic venous insufficiency, symptoms, and effective treatments such as laser therapy, compression therapy, and lifestyle changes to improve vein health and skin discoloration.