Mar 28, 2025 · Complete information for EIF5 gene (Protein Coding), Eukaryotic Translation Initiation Factor 5, including: function, proteins, disorders, pathways, orthologs, and expression.

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene. [5][6] EIF5 is a GTPase-activating protein. [7]

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S …

Sep 2, 2014 · eIF5 is the GTPase activating protein (GAP) for the eIF2·GTP·Met-tRNA iMet ternary complex with a critical role in initiation codon selection. Previous work suggested that …

Nov 26, 2018 · The N-terminal domain (NTD) of the initiation factor eIF5 bound to the 40S subunit at the precise location vacated by eIF1 promotes tRNAi accommodation at AUG codons.

The translation factor eIF5 is an important partner of eIF2, directly modulating its function in several critical steps. First, eIF5 binds eIF2/GTP/Met-tRNA (i) (Met) ternary complex (TC), …

We recently showed in a publication in Nature that the eukaryotic translation initiation factor eIF5 has a second regulatory function and is a GDI (GDP dissociation inhibitor) in addition to its …

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S …

Apr 11, 2006 · Eukaryotic initiation factor 5 (eIF5) plays multiple roles in translation initiation. Its N-terminal domain functions as a GTPase-activator protein (GAP) for GTP bound to eIF2, …

Dec 10, 2024 · Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal …