Chemokines (from Ancient Greek χῠμείᾱ (khumeíā) 'alchemy' and κῑ́νησῐς (kī́nēsis) 'movement'), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. [1][2] In addition to playing a m...

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, …

Jul 4, 2017 · Chemokines are signaling proteins secreted by cells of the immune system that stimulate the movement of other cells. Their name is reminiscent of their function since it is derived from chemotaxis, or movement in response to a chemical stimulus, and cytokines, which are small proteins implicated in cell signaling.

Chemokines are a family of chemoattractant cytokines (small proteins secreted by cells that influence the immune system) which play a vital role in cell migration through venules from blood into tissue and vice versa, and in the induction of cell movement in response to a chemical (chemokine) gradient by a process known as chemotaxis (Figure 1 ...

chemokine, any of a group of small hormonelike molecules that are secreted by cells and that stimulate the movement of cells of the immune system toward specific sites in the body.

Chemokines are chemotactic cytokines that control cell migration and cell positioning throughout development, homeostasis, and inflammation. The immune system, which is dependent on the coordinated migration of cells, is particularly dependent on chemokines for its function.

Chemokines are inflammatory mediators that have a chemotactic function in attracting leukocytes to tissues. They are produced by a number of cells, including endothelial cells, fibroblasts, and lymphocytes, and are secreted and bound to receptors on …

Mar 26, 2018 · Chemokines are generally categorized as homeostatic and inflammatory chemokines or receptors based on their major in vivo functionalities. 3, 11 However, some chemokines and GPCRs display both...

Oct 16, 2024 · Explore the intricate roles of chemokines in inflammation and disease, focusing on their structure, function, and receptor interactions. Chemokines are small signaling proteins that direct the movement of cells towards sites of inflammation, infection, and trauma.

Feb 1, 2000 · Chemokines are a group of small (∼8–14 kDa), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of seven-transmembrane, G protein–coupled receptors. About 40 chemokines have now been identified in humans.