Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The …

CCR2. CCL2 (also known as MCP1) and CCL7 (also known as MCP3) are CC chemokines that bind to CCR2 and mediate Ly6C Bright monocyte recruitment . Although expression of CCR2 …

Mar 30, 2025 · CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Polycystic Lung Disease and Human Immunodeficiency Virus …

Jan 31, 2023 · C-C chemokine receptor 2 (CCR2) is a dual-function receptor. Similar to other G protein–coupled chemokine receptors, it promotes monocyte infiltration into tissues in …

Sep 1, 2023 · C–C motif chemokine receptor 2 (CCR2), together with its ligands, especially C–C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling …

Feb 25, 2022 · The CCL2-CCR2 axis is currently the most well-studied chemokine pathway in liver disease. CCR2 and its ligands have become therapeutic targets of interest for …

Nov 5, 2024 · We have developed a CCR2 targeting Cytotoxicity Targeting Chimera (CCR2-CyTAC, STX-0712), which potently binds CCR2 on cells, and when combined with the CyTAC …

2 days ago · Monocyte recruitment was CCR2-dependent and driven by IFN-γ and CCL2 production beneath the brain vasculature. Moreover, CCR2 deficiency inhibited microglia …

Feb 8, 2025 · Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response …

Jul 18, 2022 · We showed that CCR2 overexpression was an independent prognostic marker and predicted shorter overall survival (OS) and progression-free survival (PFS) in patients with …