R-loops coordinate with SOX2 in regulating reprogramming to ...
Jun 10, 2020 · Sox2 interacts with the reprogramming barrier factor Ddx5 and inhibits the resolvase activity of Ddx5 on R-loops and thus facilitates reprogramming. Furthermore, …
Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA …
Aug 19, 2023 · In this review, we discuss the multifaceted functions of DDX5 in DNA repair in cancer, immune suppression, oncogenic metabolic rewiring, virus infection promotion, and …
DDX5 and DDX17—multifaceted proteins in the regulation of …
Sox2 interacts with DDX5 and inhibits DDX5 from resolving the R-loops, thereby promoting reprogramming (65). Therefore, DDX5 contributes to promoting smooth transcription and …
Functions of DEAD box RNA helicases DDX5 and DDX17 in …
Both RNA helicases were identified as SOX2 binding proteins in glioblastoma cells, suggesting that DDX5 may also be involved in SOX2 transcriptional activity (17). DDX5 may also …
MCM8 interacts with DDX5 to promote R-loop resolution
Jun 10, 2024 · In contrast, SOX2 facilitates somatic cell reprogramming by interacting with DDX5/DHX9 and preventing them from resolving R-loops (Li et al, 2020). Thus, R-loop …
RNA helicase DEAD box protein 5 regulates Polycomb repressive …
Herein, we identified the RNA helicase, DEAD box protein 5 (DDX5), as a regulator of SUZ12 stability and PRC2‐mediated gene repression, acting by regulating RNA‐protein complexes …
RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency
Apr 6, 2017 · DDX5 loss of function enhances reprogramming efficiency and facilitates RYBP-mediated OCT4 recruitment at the Kdm2b locus, which promotes reprogramming. This effect …
(PDF) R-loops coordinate with SOX2 in regulating ... - ResearchGate
Jun 1, 2020 · Sox2 interacts with the reprogramming barrier factor Ddx5 and inhibits the resolvase activity of Ddx5 on R-loops and thus facilitates reprogramming. Furthermore, reprogramming …
DEAD-Box RNA Binding Protein DDX5: Not a Black-Box during …
Apr 6, 2017 · DDX5 knockdown acts through RYBP on both phases by suppressing developmental genes early during the process (non-canonical PRC1 complexes with Ring1B) …
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Jun 12, 2020 · Sox2 forms a complex with Ddx5 and R-loop in cells and common targets for Sox2 and Ddx5 at R-loops are mainly associated with pluripotent genes. Furthermore, Sox2 inhibits …