- Sin1 or MAPKAP1 is a key component of mTORC2 signaling complex which is necessary for AKT phosphorylation at the S473 and T450 sites, and also for AKT downstream signaling as well.journals.plos.org/plosone/article?id=10.1371/journal.pone.0135017
MAPKAP1 Gene - GeneCards | SIN1 Protein | SIN1 …
Mar 30, 2025 · This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Sin1-mediated mTOR signaling in cell growth, …
In this review, we summarize our current knowledge of the structure and functions of Sin1, focusing specifically on its protein interaction network and its roles in the mTOR pathway that could account for various cellular functions of mTOR in …
Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR …
SIN1/MAPKAP1 is a major partner of mTORC2, acting as a scaffold and responsible for the substrate specificity of the mTOR catalytic subunit. Its overexpression promotes the …
MAPKAP1 - Wikipedia
Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene. As the name indicates, it is a subunit of mTOR complex 2.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encodi…Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 5 mins
The human stress-activated protein kinase-interacting 1 gene …
Jun 1, 2005 · Human SAPK-interacting protein 1 (Sin1) was originally identified as a partial cDNA that inhibited signalling by constitutively activated RAS2 G19V in yeast [8]. It is a member of a …
- Author: Wayne Ashley Schroder, Gillian Robin Bushell, Tom Sculley, Tom Sculley
- Publish Year: 2005
Association of mSin1 with mTORC2 Ras and Akt reveals a crucial …
mSin1 is a unique component within the mammalian target of rapamycin (mTOR) complex 2 (mTORC2), which is responsible for cellular morphology and glucose metabolism.
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79109 - Gene ResultMAPKAP1 MAPK associated protein 1 [ (human)]
Feb 9, 2025 · This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct …
The evolution of the Sin1 gene product, a little known protein ...
Feb 7, 2005 · Background: In yeast, birds and mammals, the SAPK-interacting protein 1 (Sin1) gene product has been implicated as a component of the stress-activated protein kinase …
The evolution of the Sin1 gene product, a little known protein ...
Feb 7, 2005 · SAPK-interacting protein 1 (Sin1), a little-studied but widely expressed gene product, is encoded by a single gene in fungi, nematodes, insects, and all vertebrates …
MITOGEN-ACTIVATED PROTEIN KINASE-ASSOCIATED PROTEIN 1; …
HGNC Approved Gene Symbol: MAPKAP1. SIN1, MTOR (FRAP1; 601231), RICTOR (609022), and LST8 (GBL; 612190) are components of TORC2, a protein kinase complex involved in …
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